Identifying Novel Stemness Vulnerabilities in Cancer

We are interested in understanding the general mechanism of tumorigenesis and developing strategies to prevent cancer through gaining new knowledge of the biological and molecular characteristics of cancer stem cells that are likely associated with the unfavorable outcome of this disease. Tumor types particularly prevalent in Southeast Asia and Hong Kong, including hepatocellular carcinoma, gastric cancer and esophageal squamous cell carcinoma, are currently used as model systems in our studies. Efforts are directed at conducting basic and pre-clinical studies using a combination of molecular, cellular, OMICs, and disease modelling approaches, with an ultimate goal to translate the findings in the lab into better patient care in the clinic.