Congrats to Johnson and the team! Our paper “Chemotherapy enriched THBS2-deficient cancer stem cells drive hepatocarcinogenesis through matrix softness induced histone H3 modifications” is accepted for publication in Advanced Science.
Findings of this study show that extracellular matrix remodeling by chemotherapy 5-FU enriched THBS2-deficient CD133 cancer stem cells can provide a route of escape that leads to HCC metastasis. In brief, 5-FU enriches for CD133 expressing cells with deficient THBS2 expression. THBS2, which is a known extracellular matrix (ECM)-modifying protein, has the ability to alter MMP2/MMP9 activity and thus collagen and matrix stiffness, which leads to altered cancer and stemness properties. This local soft microenvironment then induces mechano-epigenetic changes to enhance CD133 expression and suppress THBS2 expression through histone H3 modifications at their respective promoter regions, facilitating a positive feedback loop that supports the clonogenic expansion of a subpopulation of HCC cells with high CD133 expression and low THBS2 expression.
Congrats to Noel, Johnson, and the team! Read all about our story on how PRMT6 deficiency promotes autophagy in hostile HCC microenvironments via regulating BAG5/HSC70 to be soon published in Cancer Letters.
September 2020 – A warm welcome to all the new members of the team! This includes our new postdoc Yanyan, PhD students Toni and Huajian, MPhil student Yunong and MBBS student Max 🙂 Pictured is our latest gathering, celebrating a birthday COVID style.
July 18 2020 – This year’s State Key Laboratory of Liver Research (SKLLR) Annual Symposium was postponed again and again due to COVID-19. But despite all obstacles, the event was successfully held online through ZOOM on July 18th 2020. Our Postdoctoral Fellow Dr. Tin-Lok Wong gave a presentation on his latest work “CRAF methylation by PRMT6 regulates aerobic glycolysis driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation” which was just published in the April 2020 issue of Hepatology.
July 2020 – A very belated welcome to Coco and Pucci to our team. Coco joined us as a Research Assistant in late February 2020; while Pucci joined us as a BBMS Summer Intern in early July 2020. Pucci will continue on with her final year project in the lab in September. Welcome 🙂
April 2020 – Our work on “CRAF methylation by PRMT6 regulates aerobic glycolysis driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation” was commented by Drs. Amaia Navarro-Corcuera and Robert E Schwartz and featured in Hepatology Highlights.
Feb 21 2020 – Life goes on amid the COVID-19 epidemic. The team gathered for a very belated birthday celebration for Lena. We also welcome the newest members of our team Yunong, Sarah and Terry. Happy Birthday and Welcome!
Dec 9 to 12 2019 @ Awaji, Japan – Shared, learned, met new and caught up with old friends at the Cold Spring Harbor Asia 2019 Conference on Liver, Biology, Diseases and Cancer held in Awaji, Japan this year.
Jane sharing her latest research findings at the poster session.