Our PDF Lena sharing her latest findings on Prom1/CD133 heterogeneity in HCC.
Our PhD student JJ shared our latest research on using organoids to understand gastric cancer chemoresistance at the recent School of Biomedical Sciences RPG Seminar on March 12, 2021.
A very belated but warm welcome to our two new postdocs Ianto and Sara 🙂
Our Research Assistant Professor Man Tong (Carol) gave a summary of her past and current work on novel therapeutic strategies to target dysregulated signaling pathways in HCC at the School of Biomedical Sciences RAP/PDF Seminar Series on January 27, 2021.
Our postdoc Tin Lok Wong (Eric) gave a seminar on his latest work on modeling liver cancer and therapy response using driver-dependent tumor organoids derived from primary mouse liver tumors at the School of Biomedical Sciences RAP/PDF Seminar Series on January 6, 2021.
Congratulations to our RPG students for their fantastic presentations and awards at the 25th RPG Symposium! Very well done. Keep up the good work 👍
Best Oral Presentation Awards:
Jane LOONG Ho Chun (PhD student)
Matthew WONG Tsz Lam (PhD student)
Best Poster Presentation Award:
Jia Jian LOH (PhD student)
Congrats to Jane on winning one of the three Best Presentation Awards at the State Key Laboratory of Liver Research (SKLLR) Internal Research Meeting held on November 28th 2020 at HKU. A morning well spent, learning about 13 interesting HCC related projects presented by PhDs and PDFs! Well done Jane 👍
Congrats to Johnson and the team! Our paper “Chemotherapy enriched THBS2-deficient cancer stem cells drive hepatocarcinogenesis through matrix softness induced histone H3 modifications” is accepted for publication in Advanced Science.
Findings of this study show that extracellular matrix remodeling by chemotherapy 5-FU enriched THBS2-deficient CD133 cancer stem cells can provide a route of escape that leads to HCC metastasis. In brief, 5-FU enriches for CD133 expressing cells with deficient THBS2 expression. THBS2, which is a known extracellular matrix (ECM)-modifying protein, has the ability to alter MMP2/MMP9 activity and thus collagen and matrix stiffness, which leads to altered cancer and stemness properties. This local soft microenvironment then induces mechano-epigenetic changes to enhance CD133 expression and suppress THBS2 expression through histone H3 modifications at their respective promoter regions, facilitating a positive feedback loop that supports the clonogenic expansion of a subpopulation of HCC cells with high CD133 expression and low THBS2 expression.
Congrats to Noel, Johnson, and the team! Read all about our story on how PRMT6 deficiency promotes autophagy in hostile HCC microenvironments via regulating BAG5/HSC70 to be soon published in Cancer Letters.