Our joint publication with Dr Terence Lee’s team is accepted for publication in Hepatology. Congrats to Carmen, Carol and the team!
In brief, our work found SHP2 blockade by SHP099 in combination with sorafenib attenuated the adaptive resistance to sorafenib by impeding RTK-induced reactivation of the MEK/ERK and AKT signalling pathways. SHP099 in combination with sorafenib may represent a novel and safe therapeutic strategy against HCC.
Leung CO*, Tong M*, Chung KP, Zhou L, Che N, Tang KH, Ding J, Lau EY, Ng IO, Ma S^, Lee TK^. Overriding adaptive resistance to sorafenib via combination therapy with SHP2 blockade in hepatocellular carcinoma. Hepatology 2019; Epub ahead of print. *co-first authors ^co-corresponding authors
Congrats to Eric and the team on our latest paper published in Hepatology!
Our findings indicate that the PRMT6-ERK-PKM2 regulatory axis is an important determinant of the Warburg effect in HCC, and provide a mechanistic link among tumorigenicity, sorafenib resistance and glucose metabolism.Wong TL, Ng KY, Tan KV, Chan LH, Zhou L, Che N, Hoo RL, Lee TK, Richard S, Lo CM, Man K, Khong PL, Ma S. CRAF methylation by PRMT6 regulates aerobic glycolysis-driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation. Hepatology 2019; Epub ahead of print.
We welcome Yifei Wang (Research Assistant), Jia-Jian Loh (PhD student), Victoria Gao (PhD student) and Yunong Xie (Lab Intern) to the team! Lunch out on High Street at Sai Ying Pun.
Congrats to our most recent PhD graduate – Dr. Noelia Che! All the best to your new adventures at Oxford 🙂 Come visit us whenever you are back in town!
Stephanie was invited to speak at the NSFC-BHKAEC Joint Symposium on Chemistry for New Frontiers which took place in Hong Kong from 28-31 July 2019. Thank you for the opportunity!
Alan and Marco spent the past year in the lab for their Bachelor of Biomedical Sciences final year projects. Both did excellently. Congrats to you both on your graduation! All the best in your future endeavors.
Thank you for the opportunity to chair a session and speak at the 2019 Gordon Research Conference on Translational Cancer Genomics that was held in Hong Kong from June 30 to July 5 2019.