Our new paper in CMGH

Very happy to see our work on PTK7 as a novel molecular driver in metastatic HCC finally published in Cellular and Molecular Gastroenterology and Hepatology. Congrats to Matthew! Read the article here.

Findings from this study demonstrated PTK7 as a novel regulator of HCC metastasis. Specifically, we found PTK7 to be critical in driving TGF-β signaling activation, induction of metastatic phenotypes, and guiding of specific epithelial-mesenchymal transition (EMT) status.

Essays in Biochemistry – Special Issue on Cancer Stem Cells

Happy to have the opportunity to co-guest edit this special issue for Essays in Biochemistry with Terence Lee. We have assembled a nice series of reviews with contributions from Dean Tang, Alan Wong, Masaru Katoh, Stephanie Xie, Junfang Ji, Youhua Tan, Mohit Kumar Jolly, Chunzhang Yang, Xin-Yuan Guan, as well as articles from Terence and my own teams. In particular, our Ph.D. student Toni contributed a review article on ‘Mechanisms of resistance to tyrosine kinase inhibitors in liver cancer stem cells and potential therapeutic approaches.

Check it out at https://portlandpress.com/essaysbiochem/issue/66/4.

Our new paper in Cancer Research

Very happy to see our work on FSTL1+ CAFs in driving HCC stemness and metastasis finally published in the most recent issue of Cancer Research. Also out is our recently published and related mini-review article on the role of CAFs in the maintenance of stemness in the tumor microenviornment. Very well done, JJ, Carol, Natalie, and the team. We also thank our collaborators for their support.

Read the Cancer Research and Frontiers in Cell and Developmental Biology articles here.

Our new publication in Gut

Stepped out of our comfort zone and explored into lineage tracing and scRNA-seq. Years of hard work with great preserverance from our three leading authors Lena, Ken and Eric; and a wonderful collaboration with Dr. Joshua Ho. Excited to share our lab’s latest work published in Gut.

Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumor-propagating cells and their dynamic cellular transition during liver cancer progression – read all about it here!