Ecstatic to finally be able to share our latest publication in Science Translational Medicine, documenting our findings on targeting AGPAT4 to overcome liver cancer cell plasticity, from a fruitful collaboration between our cancer biology team and Prof Clive Chung’s chemical biology team. ⭐⭐


https://www.science.org/doi/10.1126/scitranslmed.adn9472

Our DGKH story now in press in Hepatology 🙌🥳

Read all about it here (PMID 39663958) and its accompanying editorial written by Prof. Guisheng Song of the University of Minnesota also published in the same journal (PMID 39666890).

Fortunate to have the opportunity to contribute a review article on Hallmarks of Cancer Stemness in the Hallmarks Reviews Series of Cell Stem Cell.

The series of review articles apply the hallmarks framework to define distinct aspects of stem cell biology, spanning from stem cell aging, metabolism, and potency to cancer stem cells and tissue regeneration. Read all about it here.

Congrats to Toni and Lena on their co-first author publication in Nature Communications!
It was a pleasure collaborating with the teams of Ming Liu of Guangzhou Medical University, XY Guan of HKUMed, Jun Yu of CUHK, Terence Lee of PolyU and Jing-Ping Yun of SYSU Cancer Centre.

Our new study uncovered a critical role for URB1-AS1, highly expressed in sorafenib-resistant HCC samples, to be key in mitigating sorafenib-induced ferroptosis through inducing ferritin phase separation and reducing cellular free iron content. Congrats to Yuan Gao, our former PDF who joined us with support from the HK Scholars Program. Read all about it in ACS Nano.

Congratulations to Eric, Jia Jian and Shixun on their co-first author publication in Nature Communications – ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer. Wonderful opportunity to collaborate with Prof SY Leung and her team at HKUMed, Prof John Copland of Mayo Clinic Florida, Prof JP Yun of SYSCC, and Prof LL Chen of CSI/NUS.

Read all about it here – PMID: 37208334,

Congrats to Huajian on her first author publication in Hepatology – SERPINA12 promotes the tumorigenic capacity of HCC stem cells through hyperactivation of AKT/β-catenin signaling.

Read all about it here – PMID: 36630996.

Very happy to see our work on PTK7 as a novel molecular driver in metastatic HCC finally published in Cellular and Molecular Gastroenterology and Hepatology. Congrats to Matthew! Read the article here.

Findings from this study demonstrated PTK7 as a novel regulator of HCC metastasis. Specifically, we found PTK7 to be critical in driving TGF-β signaling activation, induction of metastatic phenotypes, and guiding of specific epithelial-mesenchymal transition (EMT) status.

Happy to have the opportunity to co-guest edit this special issue for Essays in Biochemistry with Terence Lee. We have assembled a nice series of reviews with contributions from Dean Tang, Alan Wong, Masaru Katoh, Stephanie Xie, Junfang Ji, Youhua Tan, Mohit Kumar Jolly, Chunzhang Yang, Xin-Yuan Guan, as well as articles from Terence and my own teams. In particular, our Ph.D. student Toni contributed a review article on ‘Mechanisms of resistance to tyrosine kinase inhibitors in liver cancer stem cells and potential therapeutic approaches.

Check it out at https://portlandpress.com/essaysbiochem/issue/66/4.

Thrilled to have an opportunity to contribute a review article to the journal Hepatology. Our Ph.D. student Sheree provided a nice summary of our current understanding of noncellular components of the liver cancer stem cell niche and their potential clinical implications.